实例探究 > CSL transforms automated micro-purification with accelerated planning & data processing

CSL transforms automated micro-purification with accelerated planning & data processing

公司规模
Large Corporate
国家
  • Australia
产品
  • Synthace platform
  • Tecan Evo liquid-handling platform
技术栈
  • Cloud-based experiment platform
  • No-code interface
  • Workflow Builder
实施规模
  • Departmental Deployment
影响指标
  • Productivity Improvements
  • Digital Expertise
技术
  • 平台即服务 (PaaS) - 数据管理平台
  • 平台即服务 (PaaS) - 连接平台
适用行业
  • 医疗保健和医院
  • 生命科学
适用功能
  • 产品研发
  • 质量保证
用例
  • 预测性维护
  • 过程控制与优化
  • 实时定位系统 (RTLS)
服务
  • 云规划/设计/实施服务
  • 数据科学服务
关于客户
CSL is a leading global biotechnology company with a dynamic portfolio of lifesaving medicines, including those that treat hemophilia and immune deficiencies, vaccines to prevent influenza, and therapies in iron deficiency, dialysis, and nephrology. Since its beginnings in 1916, CSL has been driven by its promise to save lives using the latest technologies. Today, CSL – including its three businesses, CSL Behring, CSL Seqirus, and CSL Vifor – provides lifesaving products to patients in more than 100 countries and employs 30,000 people. CSL’s unique combination of commercial strength, R&D focus, and operational excellence enables the company to identify, develop and deliver innovations so its patients can live life to the fullest.
挑战
CSL set a goal of doubling the throughput of experimentation via robotics, automation & digital connectivity without a significant increase in headcount by 2030. The CSL Purification Team was looking for a solution that would enable scientists to plan and execute micro-scale purification experiments without the need to write code, ensuring their scientists could increase their throughput while improving the quality of their results. The team faced obstacles such as low uptake of automation and complicated scripting, low device utilization in lab environments, and manual management of experimental workflows & associated data. The team required a tool that would help them standardize their workflow design, execution, and data analysis processes for micro-scale purification experiments and easily transfer knowledge from one site to the next.
解决方案
The collaboration between CSL and Synthace aligned with the CSL Purification Team's goal of digital connectivity, robotics, and automation to improve process development efficiencies within the CSL Purification Team. The drag-and-drop design elements of Workflow Builder translate the CSL Purification Team's human-language directions into complex robot instructions with no custom scripting required. The in-silico simulation allows scientists to understand how their designed experiment would be physically executed on the liquid handling platform, tracking the liquids across the workflow. Synthace catches errors like impossible liquid transfers or insufficient deck space. This allows CSL Purification Team scientists to catch errors at the design stage - a great time saver, since trial runs are no longer necessary to ensure the script was set up properly ahead of the experiment. The plate reader data collected in the experiment is automatically uploaded, aligned with the liquid handling data, and analyzed by the Synthace platform without the need for manual intervention.
运营影响
  • Significant time savings in the automation of end-to-end micro-scale purification experiments on the Tecan Evo liquid-handling platform.
  • Increased automation usage and throughput within the lab.
  • Enabled the design of increasingly complex workflows by less experienced team members.
  • Enabled researchers to rapidly scale their workflow development.
数量效益
  • Up to 60% time savings on end-to-end micro-scale purification workflows.
  • Up to 50% increase in automation usage in the lab.

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