LabGenius and Antha: Combining active learning with Antha’s multifactorial optimisation for a single-stranded DNA (ssDNA) extension reaction
公司规模
11-200
地区
- Europe
国家
- United Kingdom
产品
- Antha
- EVA platform
- Gilson PIPETMAX
技术栈
- Machine Learning
- AI-driven DNA library design
- Liquid Handling Automation
实施规模
- Enterprise-wide Deployment
影响指标
- Cost Savings
- Innovation Output
- Productivity Improvements
技术
- 分析与建模 - 机器学习
- 功能应用 - 远程监控系统
- 平台即服务 (PaaS) - 数据管理平台
适用行业
- 生命科学
- 药品
适用功能
- 产品研发
- 质量保证
用例
- 数字孪生
- 质量预测分析
- 过程控制与优化
服务
- 软件设计与工程服务
- 系统集成
关于客户
LabGenius is a biotechnology company that has developed EVA, an autonomous AI-driven evolution engine for the discovery of next-generation protein therapeutics. They use their cutting-edge platform technology to develop new protein-based drugs in collaboration with world-leading pharmaceutical companies. The EVA platform utilizes an AI-driven DNA library design strategy to plan, optimize, and physically execute the production of superior quality DNA libraries encoding a host of evolved therapeutic proteins. These proteins range from enzymes to antibodies, with engineering objectives that include improved or altered binding affinity, specificity, thermostability, or resistance to proteases. LabGenius started working with Antha in 2017 and has since automated upwards of 20 unique workflows of value to them.
挑战
LabGenius faced the challenge of optimizing the single-stranded DNA (ssDNA) extension process, a critical step in their DNA library generation method. The process required different priming oligonucleotides for each ssDNA extension reaction, making it necessary to re-optimize the extension process for every new DNA library fragment. This repeated context-specific optimization was extremely challenging to execute manually due to the number of experimental runs and the complexity of the experimental designs. The need to recover maximum diversity during the single strand extension of DNA fragments encoding degeneracy was critical to the EVA platform. Manual execution within the expected time frames of DNA library generation was not feasible, necessitating an automated solution.
解决方案
LabGenius integrated Antha into their EVA platform to automate and optimize the ssDNA extension process. Antha enabled LabGenius to physically execute multifactorial experimental designs in an automated and autonomous manner. This integration allowed LabGenius to autonomously design, plan, and execute process optimization as part of their end-to-end platform. Antha's rapid and flexible digital interpretation and physical execution of complex multifactorial experimental designs provided a reusable framework to identify robust experimental conditions. This framework achieved double-stranded DNA (dsDNA) recovery efficiencies above the required minimum threshold for maximizing DNA library diversity. The automated multifactorial design interpretation, experimental planning, and execution by Antha provided significant time savings compared to manual execution. Antha's DoE suite of elements allowed LabGenius to rapidly and flexibly define an automated liquid handling protocol, simulating all low-level liquid handling instructions interpreted from a DoE design file. This facilitated the execution of experimental runs on a Gilson PIPETMAX™ liquid handling platform, providing extensive time and resource savings.
运营影响
数量效益
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