Automated Cellular Cytotoxicity Assays with Antha and Gilson PIPETMAX
公司规模
Large Corporate
地区
- Europe
国家
- United Kingdom
产品
- Antha
- Gilson PIPETMAX
技术栈
- Cloud-based platform
- Liquid handling automation
- Flow cytometry
实施规模
- Enterprise-wide Deployment
影响指标
- Innovation Output
- Productivity Improvements
- Customer Satisfaction
技术
- 功能应用 - 远程监控系统
- 分析与建模 - 预测分析
- 平台即服务 (PaaS) - 数据管理平台
适用行业
- 医疗保健和医院
- 生命科学
适用功能
- 产品研发
- 质量保证
用例
- 预测性维护
- 远程资产管理
- 数字孪生
- 远程控制
服务
- 软件设计与工程服务
- 系统集成
- 云规划/设计/实施服务
关于客户
Autolus is a leading clinical-stage biopharmaceutical company in T cell programming technologies, developing precisely targeted, controlled, and highly active Chimeric Antigen Receptor (CAR) T-cell therapies, with the potential to offer cancer patients more effective treatments and care. The company was founded on pioneering cell programming technology developed by Dr Martin Pule and was spun-out from University College London in 2014. The Synthetic Genomics research group at Autolus started working with Synthace in 2019 as it recognized the need to improve the flexibility, robustness, and efficiency of its routine CAR T-cell cytotoxicity assays. The group was looking towards automation solutions that could provide a rapid and scalable approach to physical execution in the lab, which led them to adopt Synthace’s software platform Antha.
挑战
Scientists at Autolus routinely use cytotoxicity assays in the development of novel CAR T-cell therapies. Setting up these assays manually is labour-intensive and time-consuming. While automation can increase throughput, robustness, and walkaway time for scientists, it often requires advanced coding skills. In addition, automating the handling of live cells is not straightforward as they are sensitive and susceptible to lysis.
解决方案
Synthace’s software platform Antha allows scientists to flexibly plan, test, and execute cytotoxicity assays on selected liquid handlers, with no programming needed. Users can build, simulate, and verify their assays in silico prior to scheduling a physical run. All methods and data are securely stored in the cloud for easy protocol sharing and standardization. Antha empowered Autolus to automate the setup of complex cytotoxicity assays easily, rapidly, and with the flexibility required for therapy development. Scientists showed how three different CAR-transduced effector cells significantly reduced cancer cell growth, while next generation CARs overcame inhibitory cytokine signalling, a major challenge in CAR T-cell therapies. Antha did not impact cell viability or transfer accuracy and achieved comparable results to manual execution, while offering superior pipetting consistency leading to increased assay robustness.
运营影响
数量效益
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