Case Studies > Sartorius Transforms Cell Imagery into Data with CloudFactory's Annotation Solution

Sartorius Transforms Cell Imagery into Data with CloudFactory's Annotation Solution

Company Size
1,000+
Region
  • Europe
Country
  • Germany
Product
  • IncucyteⓇ Live-Cell Analysis System
  • Dataloop
  • CloudFactory’s Data Annotation Solution
Tech Stack
  • Machine Learning
  • Artificial Intelligence
  • Data Annotation
Implementation Scale
  • Enterprise-wide Deployment
Impact Metrics
  • Customer Satisfaction
  • Innovation Output
  • Productivity Improvements
Technology Category
  • Analytics & Modeling - Machine Learning
  • Analytics & Modeling - Predictive Analytics
  • Application Infrastructure & Middleware - Data Visualization
Applicable Industries
  • Healthcare & Hospitals
Applicable Functions
  • Product Research & Development
  • Quality Assurance
Use Cases
  • Machine Condition Monitoring
  • Predictive Maintenance
  • Remote Asset Management
Services
  • Data Science Services
  • System Integration
  • Training
About The Customer
Sartorius is a biotechnology company that supports scientists and engineers in developing and manufacturing medications for incurable diseases. By simplifying workflows, enabling faster research, and reducing human error, Sartorius helps the biopharmaceutical industry bring improved medications to patients quickly and safely. One of their key products is the IncucyteⓇ Live-Cell Analysis System, which quantifies cell behavior and captures cellular changes using high-definition phase and fluorescence images. This system extracts and records image data in real-time, allowing scientists to observe complex biological changes as they happen. It also employs machine learning and artificial intelligence to help customers extract more information from samples in simple, easy ways.
The Challenge
The IncucyteⓇ Live-Cell Analysis System automates live-cell imaging, producing a vast number of microscopic images that are beyond human capacity to analyze. Neural networks can handle this task, but they require a large, annotated dataset for training. Sartorius needed to identify and characterize individual cells within these images, which contain hundreds to millions of cells in various shapes and sizes. Although the IncucyteⓇ system has integrated software for automatic cell segmentation, it requires user training and bespoke analysis for different cell types. The neural network method, however, allows for a single analysis across a wide range of cell types without user training. Faced with the diversity and volume of cells needed for the training dataset, Sartorius realized they couldn't manage the annotation process alone.
The Solution
Rickard Sjögren, a senior scientist at Sartorius, led the initiative to find a solution for the data annotation problem. After comparing several vendors, Sartorius chose to partner with CloudFactory for three main reasons: low turnover and a dedicated team of data analysts, matching values in terms of ethical workforce practices, and the combination of CloudFactory’s managed workforce with the Dataloop platform. CloudFactory’s data analysts use Dataloop to perform individual cell segmentation and identify key cell types among thousands in each image. Nicola Bevan, Manager of Cell Imaging Applications, highlighted that the combination of workforce and platform contributes to project success. CloudFactory’s trained annotators apply precision labeling techniques to complex microscopy images, even when cells are touching, out of focus, or overlapping. They also support cell tracking projects by drawing bounding boxes around cells as they move between frames in time-lapse datasets.
Operational Impact
  • With CloudFactory’s services, Sartorius has been able to considerably speed up projects.
  • The company developed an open-source dataset of more than 5,000 images, containing 1.6 million individually annotated cells, which was published in Nature Methods.
  • CloudFactory’s work helped Sartorius step into the machine learning, artificial intelligence, and image analysis spaces, leading to more informed research and better health outcomes.
  • By providing a dynamic platform for pioneers and leading experts, Sartorius is bringing creative minds together for a common goal, leading to breakthroughs that can improve health for more people.
Quantitative Benefit
  • 1.6 million cells annotated
  • More than 5,000 images in the open-source dataset
  • Many years saved in project timelines

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